Fragment Screening & FBDD

Very diverse technology platform facilitates target validation, enables fast hit finding, hit confirmation, and supports lead series optimization.

Advantages of Fragment-Based Drug Discovery

High hit rates (3-10%)
Download more information (FBDD)



Efficient sampling of chemical space


A diverse set of 1000 fragments represents its chemical space about as effectively as would 10 trillion diverse drug-sized molecules


Efficient sampling of chemical space


They can bind to small pockets available on the protein surface


Efficient sampling of chemical space

Predictor of protein druggability


Obtaining high hit rates is an excellent predictor that high-affinity, small molecule ligands can be identified.

Low hit rates (< 0.1%) strongly suggest an undruggable pocket.


Predictor of protein druggability

Often unique binding profiles


High-quality interactions between fragment and target

Often unique binding profiles


Chemical optimization


Ability to optimize pharmacokinetics profile simultaneously with potency as fragment hit grows to clinical candidate.





Fragment Screening Options

Fragment Screening Options

Example Workflow

Example Workflow

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