Spectral Shift

Traditional HTS relies on functional readouts and heavy assay development — and often misses binders essential for emerging modalities like molecular glues and bifunctional degraders.

Our spectral shift direct binding assay detects any interaction with exceptional precision, enabling:

• Up to 1,000,000 compounds screened in 2 weeks
• Minimal assay development
• Direct detection of binders, not just inhibitors
  Expand chemical space, reduce false negatives, and find hits faster.

Fragment campaigns demand sensitivity. Our technology detects even the weakest interactions with high confidence, enabling:

• Complete fragment library screen in one day
• Reliable hit identification
• Rapid progression from fragments to potent leads
  Accelerate your fragment-to-lead workflow with data you can trust.
• Use your own, WuXi AppTec's 4.6k or our new 50k extended fragment library

Covalent programs require precise binding/bonding characterization — but MS-based methods are slow, protein-hungry, and costly.

We offer a high-throughput K_inact/K_i platform in 384- and 1536-well formats that enables:

• Up to 60 compounds profiled per day
• Dramatically reduced protein consumption
• Robust, reproducible k_inact/k_i determination
  Scale your covalent discovery without scaling your costs.

PPIs are notoriously difficult due to large, flat interfaces. Our spectral shift assays deliver:

• Rapid, quantitative PPI measurements
• Efficient screening of modulators
• High sensitivity in solution
  Unlock tractable PPI discovery.

TPD discovery hinges on understanding binary and ternary complex formation — and cooperativity.

Our platform provides:

• 50-100k samples screened per day
• Fast, cost-effective binding and cooperativity data
• Direct readouts of complex formation
  Accelerate degrader discovery with biophysics built for TPD.

Membrane proteins are high-value but difficult to assay. Our technology enables binding detection in:

• Detergent
• Nanodiscs
• Liposomes
• Other native-like environments

These dynamic, flexible and important targets require sensitive, solution-based detection. Our assays support:

• Native-like conditions
• High sensitivity for weak or transient interactions
• Confident hit identification

For classic modalities, we offer rapid, high-quality profiling of:

• Affinity
• Selectivity
• K_inact/K_i
• Displacement
• Self-Association
  Streamline hit-to-lead progression across diverse target classes.

Work with proteins in their near-native environment. Our platform enables:

• Direct binding detection in crude or clarified lysates
• Early target engagement assessment
• Reduced false positives
  Ideal for unstable, low-yield, or hard-to-purify proteins.

Skip assay development entirely.

We offer >100 validated drug targets across:

• Membrane transporters
• Transcription factors
• ATPases
• Helicases
• Kinases

No protein production. No assay setup. Just immediate screening.

ML models thrive on high-quality, high-volume data.

Our platform delivers:

• 100,000 data points per day
• Fuel your ML pipelines with our ultra-fast biophysical data engine.