- Protein-ligand complexes (for example with compounds, fragments, peptides and nucleic acids)
- Fragment-based drug discovery (FBDD) and high-throughput crystallography
- Membrane proteins
- Antibody-antigen complexes
Our structural biology platform and expertise allows us to undertake a broad range of X-ray Crystallography structure-based drug discovery projects, ranging from the routine structure determination of off-the-shelf targets through to gene-to-structure projects for uncharacterized targets:
- Over 15 years of experience in all areas of X-ray Crystallography
- Extensive biophysics platform for the screening and optimization of samples prior to crystallization screening
- In-house crystallization laboratory equipped with state-of-the-art liquid handling robots and Formulatrix Rock Imager crystallization imagers for automated observation of crystallization plates
- Wide range of commercial and proprietary crystallization screens for high-throughput screening
- Beamline Partner of the Swiss Light Source and collaborations with further fourth-generation synchrotrons
- In-house Bruker V8 Venture MetalJet X-ray source for rapid screening and data collection
- State-of-the-art servers and workstations for automated data processing and structure determination
XPRESS Service
Our off-the-shelf XPRESS portfolio consists of a wide range of therapeutically relevant targets from a broad range of classes.
With established protocols for protein production and crystallization, we can provide high-quality X-ray
crystal structures with your ligand(s) of interest with a short turnaround time and high success rate.
- Over 150 targets covering all major classes
- 1-2 months’ turnaround time
View our off-the-shelf XPRESS Portfolio
XPEDITE and XPERT Services
Our gene-to-structure services cover all steps from construct design through to structure determination for characterized (XPEDITE) and uncharacterized (XPERT) targets.
Working together with the Protein Production, Biophysics and Biochemistry groups we can design, screen, produce and characterize multiple constructs in parallel.
The most suitable constructs can be screened for crystallization conditions in a high-throughput manner and promising crystallization conditions can be optimized with a wide range of approaches.
- High success rate with wide range of targets (for example kinases, helicases, transcription factors, target protein degradation, membrane proteins, protein-protein and protein-nucleic acid complexes, antibody-antigen complexes)
- 3-4 months’ turnaround time
Fragment-Based Drug Discovery and High-Throughput Crystallography
Our fragment-based drug discovery (FBDD) and high-throughput crystallography services allow the soaking large numbers of ligands (for example fragments, compounds or peptides) in parallel. We can develop and optimize soakable crystal systems, and subsequently soak 10s-100s of ligands in parallel. As a Beamline Partner of the Swiss Light Source and through our collaborations with other fourth-generation synchrotrons, we can collect diffraction data in a high-throughput manner on a weekly basis. Our automatic data processing and analysis pipelines allow rapid structure determination and the identification of bound ligands.
